HIGH RATE OF PLASMODIUM VIVAX RELAPSE FOLLOWING TREATMENT OF FALCIPARUM MALARIA IN THAILAND
Identifieur interne : 003295 ( Main/Exploration ); précédent : 003294; suivant : 003296HIGH RATE OF PLASMODIUM VIVAX RELAPSE FOLLOWING TREATMENT OF FALCIPARUM MALARIA IN THAILAND
Auteurs : Sornchai Looareesuwan [Thaïlande] ; Nicholasj. White [Thaïlande, Royaume-Uni] ; Danai Bunnag [Thaïlande] ; Sunee Chittamas [Thaïlande] ; Tranakchit Harinasuta [Thaïlande]Source :
- The Lancet [ 0140-6736 ] ; 1987.
English descriptors
- Teeft :
- Acta leidensia, Active cirrhosis, Acute falciparum malaria, Acute malaria, Antimalarial drugs, Bangkok hospital, Cirrhosis, Clin pathol, Collagen type, Disease activity, Double infection, Falciparum, Falciparum infection, Falciparum malaria, Hepatic, Hepatic forms, High rate, Hyperplasia, Initial falciparum infection, Liver biopsy, Liver disease, Liver histology, Malaria, Malaria transmission, Mefloquine, Mefloquine treatment, Monoclonal antibody, Nodular, Nodular regenerative hyperplasia, Oesophageal varices, Peripheral blood smears, Plasmodium, Plasmodium falciparum, Plasmodium vivax, Primaquine, Procollagen type, Progressive liver disease, Quinidine, Quinidine treatment, Quinine, Regenerative, Regimen, Relapse, Simultaneous inoculation, Single dose, Tropical diseases, Tropical medicine, Vivax, Vivax infection, Vivax infections, Vivax malaria, Vivax relapse, Vivax relapses.
Abstract
Abstract: Within two months of treatment for falciparum malaria, Plasmodium vivaxinfections developed in 58 (33%) of 174 patients who had received a quinine or quinidine regimen and in 46 (32%) of 145 patients who had received mefloquine with inpatient follow-up of more than six weeks. The time to vivax relapse was significantly longer after mefloquine treatment (median 47 days, range 30-65) than after quinine or quinidine treatment (21 days, 15-36; p<0·0001). All patients remained outside areas of malaria transmission. These findings suggest a very high rate of double infection in Thailand with acute suppression of vivax by falciparum malaria, and warrant evaluation of radical therapy with primaquine in certain patients with acute falciparum malaria.
Url:
DOI: 10.1016/S0140-6736(87)91479-6
Affiliations:
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The time to vivax relapse was significantly longer after mefloquine treatment (median 47 days, range 30-65) than after quinine or quinidine treatment (21 days, 15-36; p<0·0001). All patients remained outside areas of malaria transmission. These findings suggest a very high rate of double infection in Thailand with acute suppression of vivax by falciparum malaria, and warrant evaluation of radical therapy with primaquine in certain patients with acute falciparum malaria.</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li><li>Thaïlande</li></country><region><li>Angleterre</li><li>Oxfordshire</li></region><settlement><li>Oxford</li></settlement><orgName><li>Université d'Oxford</li></orgName></list><tree><country name="Thaïlande"><noRegion><name sortKey="Looareesuwan, Sornchai" sort="Looareesuwan, Sornchai" uniqKey="Looareesuwan S" first="Sornchai" last="Looareesuwan">Sornchai Looareesuwan</name></noRegion><name sortKey="Bunnag, Danai" sort="Bunnag, Danai" uniqKey="Bunnag D" first="Danai" last="Bunnag">Danai Bunnag</name><name sortKey="Chittamas, Sunee" sort="Chittamas, Sunee" uniqKey="Chittamas S" first="Sunee" last="Chittamas">Sunee Chittamas</name><name sortKey="Harinasuta, Tranakchit" sort="Harinasuta, Tranakchit" uniqKey="Harinasuta T" first="Tranakchit" last="Harinasuta">Tranakchit Harinasuta</name><name sortKey="White, Nicholasj" sort="White, Nicholasj" uniqKey="White N" first="Nicholasj." last="White">Nicholasj. White</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="White, Nicholasj" sort="White, Nicholasj" uniqKey="White N" first="Nicholasj." last="White">Nicholasj. White</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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